Hi there. Just wanted to report I'm also having the same problem.
Aspire S7-392, card reader was working fine on Windows 8 with official drivers from Acer support website. Did a normal upgrade to Windows 10 (on the Insider Preview track), and the card reader refuses to be seen. I've tried both versions of Acer's official drivers, I've tried the newest from Realtek's website, I've tried a few other manufacturers' versions, none of them do anything.
The card reader isn't seen in the Device Manager at all. When I open [Dev Manager/Universal Serial Bus controllers/Generic USB Hub/], I can't see it in either the Power or Advanced tabs, even after hitting Refresh or Reset Hub (with all different driver versions). Would like to be able to use my card reader again!
